This paper introduces the technological innovation of desertification control in the Kubuqi Desert that is the seventh largest desert in China. After 30 years of comprehensive treatment, Kubuqi Desert has become the first desert in the world to be largely treated. By means of physics, chemistry and biology methods, scientists and technicians have created a lot of effective desertification control methods for Kubuqi. These methods not only improve the efficiency of Kubuqi desertification control, but also have important reference and promotion significance to other desertified areas in the world.